NANP

Across TCGA cell cohorts, NANP mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NANP-associated genes across cancer lineages are NUPR2, MS4A18, and ADAM7. Each is linked with NANP in more than 1 cancer types. Because this analysis shows association rather than direction, both NANP-to-partner and partner-to-NANP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUPR2 grouped by NANP-low versus NANP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NANP→partner) and Y-score (partner→NANP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NUPR2 →	+0.074	+5.539	<.001	.003	3	1
LARGE_INTESTINE	MS4A18 →	+0.028	+4.095	<.001	.009	3	1
LARGE_INTESTINE	ADAM7 →	+0.007	+4.930	<.001	.001	3	1
LARGE_INTESTINE	F11 →	+0.073	+4.467	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR4F4 →	+0.012	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	DPRX →	+0.328	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

NUPR2 by NANP expression — BLOOD_Leukemia

Explore this box plot interactively →