Across TCGA pan-cancer cohorts, NANOS2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of NANOS2’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where NANOS2 RNA is repressed in tumor relative to normal tissue. In most cancer types NANOS2 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

BRCA and KICH are the cancer types where NANOS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NANOS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	−0.012	.042	2	view →
KICH	All	All	−0.015	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: NANOS2 RNA expression & survival · all NANOS2 data types