Across TCGA patient cohorts, NANOS1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NANOS1-associated genes across cancer lineages are ERK2, GAPDH, and Myosin-IIa_pS1943. Each is linked with NANOS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NANOS1-to-partner and partner-to-NANOS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NANOS1→partner) and Y-score (partner→NANOS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.414	+3.321	<.001	.010	3	1
UCEC	GAPDH →	+0.853	+3.321	.002	.010	3	1
UCEC	Myosin-IIa_pS1943 →	+0.249	+3.335	.021	.005	3	1
UCEC	Myosin-IIa →	+0.295	+3.014	.002	.018	3	1
UCEC	p21 →	+0.212	+3.321	.035	.010	3	1
UCEC	p62 Lck ligand →	+0.494	+3.321	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

NANOS1 survival (RNA) · tumor vs normal (RNA) · all NANOS1 data types