NANOGP4

Across TCGA pan-cancer cohorts, NANOGP4 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated NANOGP4 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher NANOGP4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NANOGP4 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCS show a favorable association.

UVM, LUSC, and UCEC are the cancer types where NANOGP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.358	0.794	<.001	108	view →
LUSC	DFS	Median	II,III,IV	0.586	0.779	<.001	51	view →
UCEC	OS	Tertile	All	0.894	0.936	.007	46	view →
BRCA	OS	Quartile	III,IV	0.904	0.793	.015	30	view →
ACC	DFS	Median	IV	0.173	0.481	.011	27	view →
UCS	OS	Median	IV	0.844	0.234	.005	26	view →
KIRP	DFS	Quartile	II,III,IV	0.209	0.591	.018	21	view →
STAD	DFS	Tertile	All	0.267	0.483	.020	20	view →
LGG	OS	Quartile	All	0.690	0.826	<.001	15	view →
DLBC	DFS	Quartile	II,III,IV	0.516	1.000	.010	10	view →
COAD	DFS	Tertile	III,IV	0.431	0.724	.009	9	view →
KICH	DFS	Tertile	III,IV	0.043	0.897	.045	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

NANOGP4–UVM (DFS)

Open the UVM breakdown →