Across TCGA pan-cancer cohorts, NANOGNB Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated NANOGNB data layer compared with 12 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher NANOGNB Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated NANOGNB expression acts as an unfavorable survival marker.

LIHC and UCEC are the cancer types where NANOGNB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: NANOGNB tumor-vs-normal RNA expression · all NANOGNB data types