NANOG

Across TCGA patient cohorts, NANOG mutation is significantly associated with the RNA expression of many other genes, with 687 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NANOG-associated genes across cancer lineages are RNA5SP410, RNA5SP413, and RNA5SP417. Each is linked with NANOG in more than 1 cancer types. Because this analysis shows association rather than direction, both NANOG-to-partner and partner-to-NANOG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP410 grouped by NANOG-low versus NANOG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NANOG→partner) and Y-score (partner→NANOG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP410 →	+0.933	+2.789	<.001	<.001	3	2
UCEC	RNA5SP413 →	+1.856	+3.125	<.001	<.001	3	2
UCEC	RNA5SP417 →	+0.766	+2.503	<.001	.004	3	2
UCEC	RNA5SP422 →	+1.243	+2.671	<.001	.001	3	2
UCEC	RNU6-218P →	+0.496	+2.760	.001	<.001	3	2
UCEC	RNA5SP423 →	+1.045	+2.717	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 687 associations by consensus.

RNA5SP410 by NANOG expression — UCEC

Explore this box plot interactively →