NANOG

Across TCGA cell cohorts, NANOG mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NANOG-associated genes across cancer lineages are LHCGR and OR6Q1. Each is linked with NANOG in more than 1 cancer types. Because this analysis shows association rather than direction, both NANOG-to-partner and partner-to-NANOG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LHCGR grouped by NANOG-low versus NANOG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NANOG→partner) and Y-score (partner→NANOG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LHCGR →	+0.050	+4.467	<.001	.004	3	1
LARGE_INTESTINE	OR6Q1 →	+0.022	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

LHCGR by NANOG expression — LARGE_INTESTINE

Explore this box plot interactively →