NAMPT

Across TCGA patient cohorts, NAMPT mutation is significantly associated with the RNA expression of many other genes, with 3,388 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAMPT-associated genes across cancer lineages are SNORD32B, XAGE1A, and RNU6-679P. Each is linked with NAMPT in more than 1 cancer types. Because this analysis shows association rather than direction, both NAMPT-to-partner and partner-to-NAMPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD32B grouped by NAMPT-low versus NAMPT-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAMPT→partner) and Y-score (partner→NAMPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SNORD32B →	+0.420	+6.357	<.001	<.001	3	2
HNSC	XAGE1A →	+0.082	+5.008	<.001	.004	3	2
HNSC	RNU6-679P →	+0.350	+5.763	<.001	.001	3	2
BRCA	RNU6-374P →	+0.142	+8.057	<.001	.005	3	2
LUAD	GAGE2A →	+1.685	+4.841	<.001	<.001	3	2
HNSC	LINC00564 →	+0.268	+5.339	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,388 associations by consensus.

SNORD32B by NAMPT expression — HNSC

Explore this box plot interactively →