NAMPT

Across TCGA patient cohorts, NAMPT mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAMPT-associated genes across cancer lineages are 4E-BP1, C-Raf, and 14-3-3_beta. Each is linked with NAMPT in more than 1 cancer types. Because this analysis shows association rather than direction, both NAMPT-to-partner and partner-to-NAMPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by NAMPT-low versus NAMPT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAMPT→partner) and Y-score (partner→NAMPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.243	+3.321	.009	.009	3	2
UCEC	C-Raf →	+0.135	+2.321	.006	.005	3	2
UCEC	14-3-3_beta →	-0.083	-1.427	.017	.024	3	1
UCEC	eEF2 →	+0.346	+2.000	.005	.029	3	1
UCEC	EGFR_pY1068 →	-0.272	-3.000	.001	<.001	3	1
UCEC	eIF4G →	+0.290	+2.115	.007	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

4E-BP1 by NAMPT expression — UCEC

Explore this box plot interactively →