NAMPT

Across TCGA cell cohorts, NAMPT mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NAMPT-associated genes across cancer lineages are PRLHR, OR13J1, and OR13D1. Each is linked with NAMPT in more than 1 cancer types. Because this analysis shows association rather than direction, both NAMPT-to-partner and partner-to-NAMPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRLHR grouped by NAMPT-low versus NAMPT-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAMPT→partner) and Y-score (partner→NAMPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRLHR →	+0.015	+5.022	<.001	.002	3	1
SKIN	OR13J1 →	+0.055	+4.095	<.001	.009	3	1
SKIN	OR13D1 →	+0.038	+4.930	<.001	.001	3	1
SKIN	OR52L1 →	+0.038	+4.467	<.001	.004	3	1
SKIN	SLC36A2 →	+0.045	+4.684	<.001	.002	3	1
SKIN	RBMY1E →	+0.204	+5.562	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

PRLHR by NAMPT expression — SKIN

Explore this box plot interactively →