NAIP

Across TCGA patient cohorts, NAIP mutation is significantly associated with the RNA expression of many other genes, with 147 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAIP-associated genes across cancer lineages are PSMC1P8, DEFB4B, and KRTAP19-2. Each is linked with NAIP in more than 1 cancer types. Because this analysis shows association rather than direction, both NAIP-to-partner and partner-to-NAIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMC1P8 grouped by NAIP-low versus NAIP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAIP→partner) and Y-score (partner→NAIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PSMC1P8 →	+0.043	+2.848	<.001	.004	3	2
LGG	DEFB4B →	+0.119	+7.977	<.001	.007	3	1
LGG	KRTAP19-2 →	+0.114	+7.977	<.001	.007	3	1
LGG	MIR509-1 →	+0.373	+7.977	<.001	.007	3	1
LGG	MIR4303 →	+0.472	+7.977	<.001	.007	3	1
BLCA	RNU5F-3P →	+0.389	+5.788	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 147 associations by consensus.

PSMC1P8 by NAIP expression — SKCM

Explore this box plot interactively →