NAIP

Across TCGA patient cohorts, NAIP mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAIP-associated genes across cancer lineages are STAT5a, Axl, and VHL. Each is linked with NAIP in more than 1 cancer types. Because this analysis shows association rather than direction, both NAIP-to-partner and partner-to-NAIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT5a grouped by NAIP-low versus NAIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAIP→partner) and Y-score (partner→NAIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT5a →	+0.471	+3.000	.041	.037	3	1
UCEC	Axl →	+0.321	+3.036	.007	.018	3	1
UCEC	VHL →	-0.814	-3.000	.038	.037	3	1
UCEC	Lck →	+0.306	+3.000	.008	.037	2	1
UCEC	14-3-3_zeta →	+0.248	+3.026	.037	.019	2	1
UCEC	FASN →	-0.706	-3.000	.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

STAT5a by NAIP expression — UCEC

Explore this box plot interactively →