NAIP

Across TCGA cell cohorts, NAIP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,433 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NAIP-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Positive regulation of intracellular steroid hormone receptor signaling pathway, and Regulation of alternative mRNA splicing, via spliceosome. Each is linked with NAIP in more than 12 cancer types. Because this analysis shows association rather than direction, both NAIP-to-partner and partner-to-NAIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair grouped by NAIP-low versus NAIP-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NAIP→partner) and Y-score (partner→NAIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of double-strand break repair →	+0.083	+1.448	<.001	<.001	3	13
URINARY_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.144	+1.011	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of alternative mRNA splicing, via spliceosome →	+0.105	+0.971	<.001	<.001	3	13
BONE	Positive regulation of DNA metabolic process →	+0.063	+1.210	<.001	<.001	3	13
LUNG_SCLC	Regulation of cilium assembly →	+0.046	+1.179	<.001	.003	3	11
BONE	Viral transcription →	+0.091	+1.639	.005	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,433 associations by consensus.

Positive regulation of double-strand break repair by NAIP expression — BONE

Explore this box plot interactively →