NAIF1

Across TCGA pan-cancer cohorts, NAIF1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of NAIF1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NAIF1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NAIF1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where NAIF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NAIF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.695	<.001	11	view →
COAD	Female	All	+0.371	<.001	10	view →
LIHC	Female	II,III,IV	+0.961	<.001	9	view →
THCA	All	All	−0.208	<.001	9	view →
BLCA	All	All	+0.594	<.001	8	view →
STAD	Male	II,III,IV	+0.770	<.001	7	view →
CHOL	All	All	+1.201	<.001	5	view →
KICH	Male	All	−0.652	<.001	5	view →
UCEC	All	All	−0.313	.014	2	view →
BRCA	All	II,III,IV	+0.135	.040	2	view →
ESCA	All	All	+0.432	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

NAIF1–HNSC

Open the HNSC breakdown →