NAGS

Across TCGA patient cohorts, NAGS mutation is significantly associated with the RNA expression of many other genes, with 948 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAGS-associated genes across cancer lineages are RNA5SP226, HMGN2P31, and PMS2P11. Each is linked with NAGS in more than 1 cancer types. Because this analysis shows association rather than direction, both NAGS-to-partner and partner-to-NAGS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP226 grouped by NAGS-low versus NAGS-high in KIRP.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAGS→partner) and Y-score (partner→NAGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	RNA5SP226 →	+0.381	+5.159	<.001	.007	3	2
UCEC	HMGN2P31 →	+0.506	+3.375	<.001	<.001	3	2
UCEC	PMS2P11 →	+0.074	+2.833	.002	.002	3	2
LUSC	CHCHD2P1 →	+0.110	+5.404	<.001	.005	3	2
HNSC	RNA5SP429 →	+0.501	+4.452	<.001	.006	3	1
UCEC	SSRP1 →	+0.666	+3.202	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 948 associations by consensus.

RNA5SP226 by NAGS expression — KIRP

Explore this box plot interactively →