NAGS

Across TCGA patient cohorts, NAGS mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAGS-associated genes across cancer lineages are Ku80, PDCD4, and ATM. Each is linked with NAGS in more than 1 cancer types. Because this analysis shows association rather than direction, both NAGS-to-partner and partner-to-NAGS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by NAGS-low versus NAGS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAGS→partner) and Y-score (partner→NAGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.269	+3.013	.049	.019	3	1
UCEC	PDCD4 →	-0.568	-3.000	.036	.037	3	1
UCEC	ATM →	-0.550	-3.000	.036	.037	2	1
UCEC	Caspase-7-cleavedD198 →	+1.109	+3.000	.001	.037	2	1
UCEC	4E-BP1 →	+0.353	+3.000	.024	.037	1	1
UCEC	eEF2K →	+0.413	+3.013	.040	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Ku80 by NAGS expression — UCEC

Explore this box plot interactively →