NAGS

Across TCGA cell cohorts, NAGS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,363 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NAGS-associated GO terms across cancer lineages are L-arginine biosynthetic process, Intracellular glutamate homeostasis, and Exploration behavior. Each is linked with NAGS in more than 9 cancer types. Because this analysis shows association rather than direction, both NAGS-to-partner and partner-to-NAGS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-arginine biosynthetic process grouped by NAGS-low versus NAGS-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NAGS→partner) and Y-score (partner→NAGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	L-arginine biosynthetic process →	-0.285	-1.494	<.001	.001	2	10
OESOPHAGUS	Intracellular glutamate homeostasis →	-0.171	-1.013	.002	.001	3	8
BREAST	Exploration behavior →	+0.132	+0.642	<.001	.005	3	8
BREAST	Microglia development →	-0.128	-0.670	.001	<.001	3	8
BONE	Wound healing →	+0.109	+0.823	<.001	<.001	3	7
OVARY	Positive regulation of ferroptosis →	+0.096	+0.527	.004	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,363 associations by consensus.

L-arginine biosynthetic process by NAGS expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →