NAGPA

Across TCGA pan-cancer cohorts, NAGPA mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NAGPA data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NAGPA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NAGPA expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where NAGPA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.139	0.979	.001	21	view →
HNSC	DFS	Median	III,IV	0.882	1.000	.009	8	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.221	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NAGPA–CCRCC (DFS)

Open the CCRCC breakdown →