NAGPA

Across TCGA pan-cancer cohorts, NAGPA mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of NAGPA’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NAGPA mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types NAGPA is over-expressed in tumor, although a few such as LSCC and PDAC show the opposite, repressed pattern.

HNSC, LUAD, and LSCC are the cancer types where NAGPA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NAGPA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.460	<.001	8	view →
LUAD	Male	II,III,IV	+0.315	.001	4	view →
LSCC	Male	All	−0.144	.019	2	view →
PDAC	Male	All	−0.561	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

NAGPA–HNSC

Open the HNSC breakdown →