NAGPA

Across TCGA patient cohorts, NAGPA mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAGPA-associated genes across cancer lineages are E-Cadherin, A-Raf_pS299, and IGFBP2. Each is linked with NAGPA in more than 1 cancer types. Because this analysis shows association rather than direction, both NAGPA-to-partner and partner-to-NAGPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, E-Cadherin grouped by NAGPA-low versus NAGPA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAGPA→partner) and Y-score (partner→NAGPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	E-Cadherin →	-0.791	-2.991	.016	.036	3	2
UCEC	A-Raf_pS299 →	-0.139	-2.321	.020	.035	3	1
UCEC	IGFBP2 →	-0.868	-2.321	.007	.035	3	1
UCEC	Ku80 →	+0.299	+3.472	.011	.002	3	1
UCEC	MEK1 →	+0.501	+3.169	.006	.019	3	1
UCEC	Notch1 →	+0.148	+2.321	.036	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

E-Cadherin by NAGPA expression — COAD

Explore this box plot interactively →