NAGPA

Across TCGA cell cohorts, NAGPA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,200 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NAGPA-associated GO terms across cancer lineages are Vacuolar transport, Multi-pass transmembrane protein insertion into ER membrane, and Lysosome organization. Each is linked with NAGPA in more than 12 cancer types. Because this analysis shows association rather than direction, both NAGPA-to-partner and partner-to-NAGPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vacuolar transport grouped by NAGPA-low versus NAGPA-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NAGPA→partner) and Y-score (partner→NAGPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Vacuolar transport →	+0.080	+1.125	<.001	<.001	3	13
CNS	Multi-pass transmembrane protein insertion into ER membrane →	+0.117	+0.718	<.001	.003	3	13
UPPER_AERODIGESTIVE_TRACT	Lysosome organization →	+0.085	+1.031	<.001	<.001	3	12
LARGE_INTESTINE	Calcium-independent cell-matrix adhesion →	+0.156	+0.404	<.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Lytic vacuole organization →	+0.085	+1.031	<.001	<.001	3	12
BONE	Establishment of protein localization to vacuole →	+0.069	+0.663	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,200 associations by consensus.

Vacuolar transport by NAGPA expression — BONE

Explore this box plot interactively →