NAGPA

Across TCGA cell cohorts, NAGPA mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NAGPA-associated genes across cancer lineages are AVP, DYNAP, and RNASE9. Each is linked with NAGPA in more than 1 cancer types. Because this analysis shows association rather than direction, both NAGPA-to-partner and partner-to-NAGPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by NAGPA-low versus NAGPA-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAGPA→partner) and Y-score (partner→NAGPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.038	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	DYNAP →	+0.095	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	RNASE9 →	+0.012	+5.209	.001	.005	3	1
LARGE_INTESTINE	C8A →	+0.018	+2.777	<.001	.004	3	1
LARGE_INTESTINE	TEX33 →	+0.027	+2.560	<.001	.008	3	1
LARGE_INTESTINE	KCNJ5 →	+0.696	+3.215	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

AVP by NAGPA expression — BLOOD_Lymphoma

Explore this box plot interactively →