NAGPA-AS1

Across TCGA pan-cancer cohorts, NAGPA-AS1 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated NAGPA-AS1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher NAGPA-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NAGPA-AS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and ACC show a favorable association.

UCS, THCA, and BLCA are the cancer types where NAGPA-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	All	0.105	0.711	<.001	144	view →
THCA	OS	Tertile	All	0.701	0.934	<.001	90	view →
BLCA	OS	Tertile	All	0.066	0.694	<.001	72	view →
KIRP	OS	Tertile	II,III,IV	0.111	0.769	<.001	69	view →
PAAD	DFS	Tertile	All	0.782	0.458	.010	18	view →
LUAD	DFS	Tertile	IV	0.511	0.978	<.001	18	view →
LAML	DFS	Tertile	All	0.175	0.495	.015	18	view →
UCEC	OS	Tertile	IV	0.308	0.748	.009	18	view →
ACC	OS	Tertile	II,III,IV	1.000	0.483	.013	14	view →
HNSC	OS	Tertile	II,III,IV	0.617	0.768	.010	12	view →
THYM	DFS	Tertile	All	0.092	0.871	<.001	9	view →
KICH	DFS	Tertile	III,IV	0.353	0.818	.035	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

NAGPA-AS1–UCS (OS)

Open the UCS breakdown →