NAGLU

Across TCGA cell cohorts, NAGLU mutation is significantly associated with the RNA expression of many other genes, with 207 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NAGLU-associated genes across cancer lineages are UBE2G1, ZFAND4, and ANKRD30BL. Each is linked with NAGLU in more than 1 cancer types. Because this analysis shows association rather than direction, both NAGLU-to-partner and partner-to-NAGLU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2G1 grouped by NAGLU-low versus NAGLU-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAGLU→partner) and Y-score (partner→NAGLU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UBE2G1 →	+0.547	+2.537	.005	.008	3	2
LARGE_INTESTINE	ZFAND4 →	+1.107	+3.502	<.001	.001	3	2
BLOOD_Leukemia	ANKRD30BL →	+0.607	+2.967	<.001	.003	3	2
BLOOD_Leukemia	C4orf50 →	+0.135	+3.237	.005	.002	3	2
KIDNEY	IFNA2 →	+0.080	+5.000	<.001	.005	3	1
URINARY_TRACT	SEL1L2 →	+0.030	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 207 associations by consensus.

UBE2G1 by NAGLU expression — LARGE_INTESTINE

Explore this box plot interactively →