NAF1

Across TCGA pan-cancer cohorts, NAF1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NAF1 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NAF1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NAF1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where NAF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	1.000	0.862	.004	29	view →
CCRCC	DFS	Tertile	All	0.836	0.585	.010	12	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.758	.008	8	view →
PDAC	OS	Median	III,IV	0.197	0.580	.010	3	view →
HNSC	DFS	Median	All	0.554	0.712	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NAF1–LUAD (OS)

Open the LUAD breakdown →