NAE1

Across TCGA pan-cancer cohorts, NAE1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NAE1 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NAE1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NAE1 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC, LSCC, and GBM are the cancer types where NAE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.140	1.000	.017	24	view →
LSCC	DFS	Tertile	III,IV	0.400	0.918	.006	13	view →
GBM	OS	Tertile	All	0.711	0.392	.002	10	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NAE1–HNSC (OS)

Open the HNSC breakdown →