NAE1

Across TCGA patient cohorts, NAE1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,944 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NAE1-associated genes across cancer lineages are DDX19B, ZNF620, and SF3B3. Each is linked with NAE1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NAE1-to-partner and partner-to-NAE1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NAE1 versus DDX19B in LSCC, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAE1→partner) and Y-score (partner→NAE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DDX19B →	+0.488	+0.179	<.001	<.001	3	5
LSCC	ZNF620 →	+0.553	+0.117	<.001	<.001	3	5
COAD	SF3B3 →	+0.609	+0.096	.007	.008	3	5
LSCC	ACVR2B-AS1 →	+0.525	+0.145	<.001	.001	3	5
BRCA	UBA3 →	+0.469	+0.208	.002	<.001	3	5
LSCC	SETD6 →	+0.582	+0.193	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,944 associations by consensus.

NAE1 vs DDX19B — LSCC

Explore this scatter interactively →