NAE1

Across TCGA patient cohorts, NAE1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAE1-associated genes across cancer lineages are Cyclin-B1, Notch1, and Annexin-1. Each is linked with NAE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NAE1-to-partner and partner-to-NAE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by NAE1-low versus NAE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAE1→partner) and Y-score (partner→NAE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.642	+3.906	<.001	<.001	3	3
UCEC	Notch1 →	+0.135	+1.594	.004	.021	3	2
UCEC	Annexin-1 →	+0.373	+1.720	.037	.025	3	2
UCEC	TFRC →	+0.379	+1.874	.036	.049	3	2
UCEC	Caspase-8 →	-0.215	-2.388	.011	.002	3	2
UCEC	C-Raf →	+0.159	+2.222	.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Cyclin-B1 by NAE1 expression — UCEC

Explore this box plot interactively →