NAE1

Across TCGA cell cohorts, NAE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,106 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NAE1-associated GO terms across cancer lineages are DNA strand elongation, DNA-templated DNA replication, and Double-strand break repair via homologous recombination. Each is linked with NAE1 in more than 18 cancer types. Because this analysis shows association rather than direction, both NAE1-to-partner and partner-to-NAE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA strand elongation grouped by NAE1-low versus NAE1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NAE1→partner) and Y-score (partner→NAE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation →	+0.211	+1.174	<.001	<.001	3	19
BLOOD_Myeloma	DNA-templated DNA replication →	+0.134	+1.227	<.001	<.001	3	18
BLOOD_Myeloma	Double-strand break repair via homologous recombination →	+0.076	+1.161	<.001	<.001	3	17
BLOOD_Myeloma	DNA replication initiation →	+0.180	+1.171	<.001	<.001	3	17
BLOOD_Myeloma	7-methylguanosine mRNA capping →	+0.099	+0.810	.001	.005	2	18
BLOOD_Myeloma	7-methylguanosine RNA capping →	+0.099	+0.810	.001	.005	2	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,106 associations by consensus.

DNA strand elongation by NAE1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →