NAE1

Across TCGA cell cohorts, NAE1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NAE1-associated genes across cancer lineages are TACR3, PRND, and TEX43. Each is linked with NAE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAE1-to-partner and partner-to-NAE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TACR3 grouped by NAE1-low versus NAE1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAE1→partner) and Y-score (partner→NAE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TACR3 →	+0.043	+5.060	<.001	.001	3	1
BLOOD_Leukemia	PRND →	+0.011	+4.874	<.001	.002	3	1
BLOOD_Leukemia	TEX43 →	+0.105	+4.969	<.001	.003	3	1
BLOOD_Leukemia	CCT8L2 →	+0.019	+4.874	<.001	.002	3	1
BLOOD_Leukemia	OC90 →	+0.012	+5.786	<.001	<.001	3	1
BLOOD_Leukemia	OR1D4 →	+0.046	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

TACR3 by NAE1 expression — BLOOD_Leukemia

Explore this box plot interactively →