NADSYN1

Across TCGA pan-cancer cohorts, NADSYN1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NADSYN1 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NADSYN1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NADSYN1 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LUAD, PDAC, and LSCC are the cancer types where NADSYN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.610	0.883	.011	6	view →
PDAC	DFS	Tertile	All	0.807	0.731	.028	5	view →
LSCC	DFS	Median	All	0.608	0.937	.021	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NADSYN1–LUAD (OS)

Open the LUAD breakdown →