NADSYN1

Across TCGA pan-cancer cohorts, NADSYN1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of NADSYN1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NADSYN1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types NADSYN1 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, LUAD, and LSCC are the cancer types where NADSYN1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NADSYN1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.326	<.001	10	view →
LUAD	Male	III,IV	+0.412	<.001	9	view →
LSCC	Male	All	+0.300	<.001	7	view →
CCRCC	Male	All	+0.207	<.001	6	view →
HNSC	Male	IV	−0.209	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

NADSYN1–COAD

Open the COAD breakdown →