NADSYN1

Across TCGA patient cohorts, NADSYN1 mutation is significantly associated with the RNA expression of many other genes, with 2,177 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NADSYN1-associated genes across cancer lineages are OR4X2, NBEAP3, and GCH1. Each is linked with NADSYN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NADSYN1-to-partner and partner-to-NADSYN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by NADSYN1-low versus NADSYN1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NADSYN1→partner) and Y-score (partner→NADSYN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	OR4X2 →	+0.125	+4.290	.003	.008	3	3
SKCM	NBEAP3 →	+0.028	+4.089	.003	<.001	3	3
UCEC	GCH1 →	+0.732	+2.555	<.001	<.001	3	3
UCEC	BLOC1S3 →	+0.347	+2.555	.002	<.001	3	2
UCEC	TRAPPC4 →	+0.344	+2.566	.003	<.001	3	2
UCEC	ZNF808 →	+0.298	+2.202	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,177 associations by consensus.

OR4X2 by NADSYN1 expression — STAD

Explore this box plot interactively →