NADSYN1

Across TCGA patient cohorts, NADSYN1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NADSYN1-associated genes across cancer lineages are ER-alpha_pS118, A-Raf_pS299, and p21. Each is linked with NADSYN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NADSYN1-to-partner and partner-to-NADSYN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha_pS118 grouped by NADSYN1-low versus NADSYN1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NADSYN1→partner) and Y-score (partner→NADSYN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	ER-alpha_pS118 →	+0.128	+2.853	.017	.034	3	2
UCEC	A-Raf_pS299 →	-0.150	-2.807	<.001	.003	3	2
UCEC	p21 →	+0.157	+3.183	.029	.009	3	2
UCEC	PI3K-p110-a →	-0.173	-2.662	.008	<.001	3	2
UCEC	RAD51 →	+0.111	+2.321	.034	.033	3	2
UCEC	ATM →	-0.648	-3.687	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

ER-alpha_pS118 by NADSYN1 expression — LUSC

Explore this box plot interactively →