NADSYN1

Across TCGA cell cohorts, NADSYN1 mutation is significantly associated with the drug of many other genes, with 49 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NADSYN1-associated genes across cancer lineages are 5-Fluorouracil, RVX-208, and AZD5153. Each is linked with NADSYN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NADSYN1-to-partner and partner-to-NADSYN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 5-Fluorouracil grouped by NADSYN1-low versus NADSYN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NADSYN1→partner) and Y-score (partner→NADSYN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	5-Fluorouracil →	+0.580	+2.991	.035	.018	3	1
LARGE_INTESTINE	RVX-208 →	+0.398	+2.868	.005	.022	3	1
LARGE_INTESTINE	AZD5153 →	+0.517	+2.871	.030	.021	3	1
LARGE_INTESTINE	615590 →	+0.280	+2.684	.039	.035	3	1
LARGE_INTESTINE	Brivanib →	+0.343	+2.874	.038	.021	3	1
LARGE_INTESTINE	ETP-45835 →	+0.254	+2.874	.026	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

5-Fluorouracil by NADSYN1 expression — LARGE_INTESTINE

Explore this box plot interactively →