NADK2

Across TCGA patient cohorts, NADK2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NADK2-associated genes across cancer lineages are FoxM1, FOXO3a_pS318_S321, and JNK_pT183_Y185. Each is linked with NADK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NADK2-to-partner and partner-to-NADK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by NADK2-low versus NADK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NADK2→partner) and Y-score (partner→NADK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.289	+2.459	.020	.020	3	1
UCEC	FOXO3a_pS318_S321 →	-0.132	-2.999	.028	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.264	-3.571	.001	.002	3	1
UCEC	JNK2 →	+0.272	+2.179	.004	.034	3	1
UCEC	Ku80 →	+0.396	+3.598	<.001	.001	3	1
UCEC	MEK1 →	+0.399	+3.169	.023	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

FoxM1 by NADK2 expression — UCEC

Explore this box plot interactively →