NACC2

Across TCGA pan-cancer cohorts, NACC2 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated NACC2 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NACC2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NACC2 expression acts as an unfavorable survival marker.

LSCC and LUAD are the cancer types where NACC2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.517	0.866	.004	15	view →
LUAD	OS	Median	III,IV	0.268	0.721	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

NACC2–LSCC (DFS)

Open the LSCC breakdown →