NACC2

Across TCGA patient cohorts, NACC2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. COAD shows the largest number of these associations.

The most reproducible NACC2-associated genes across cancer lineages are eIF4E, PDCD4, and ASNS. Each is linked with NACC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NACC2-to-partner and partner-to-NACC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NACC2-low versus NACC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NACC2→partner) and Y-score (partner→NACC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.206	+2.183	.021	.033	3	2
COAD	PDCD4 →	-0.439	-2.991	.044	.036	3	2
COAD	ASNS →	+0.611	+3.008	.002	.019	3	2
UCEC	A-Raf_pS299 →	-0.134	-2.321	.008	.034	3	1
UCEC	ERK2 →	+0.181	+2.906	.027	.001	3	1
UCEC	FoxM1 →	+0.256	+3.179	.019	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eIF4E by NACC2 expression — UCEC

Explore this box plot interactively →