NACC2

Across TCGA cell cohorts, NACC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,452 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NACC2-associated GO terms across cancer lineages are Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage, Regulation of modification of synaptic structure, and Protein depolymerization. Each is linked with NACC2 in more than 13 cancer types. Because this analysis shows association rather than direction, both NACC2-to-partner and partner-to-NACC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage grouped by NACC2-low versus NACC2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NACC2→partner) and Y-score (partner→NACC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage →	-0.098	-1.186	<.001	<.001	3	14
OESOPHAGUS	Regulation of modification of synaptic structure →	+0.148	+0.892	.001	.009	3	13
SOFT_TISSUE	Protein depolymerization →	+0.121	+1.294	<.001	<.001	3	11
OVARY	Response to epidermal growth factor →	+0.083	+0.602	<.001	<.001	3	11
OVARY	Cellular response to epidermal growth factor stimulus →	+0.077	+0.577	<.001	<.001	3	11
SKIN	Cytosolic transport →	+0.073	+1.116	<.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,452 associations by consensus.

Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by NACC2 expression — BREAST

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