NACC1

Across TCGA pan-cancer cohorts, NACC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NACC1 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NACC1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NACC1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where NACC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.559	0.863	<.001	65	view →
CCRCC	OS	Median	All	0.900	0.985	.019	13	view →
LSCC	DFS	Median	II,III,IV	1.000	0.854	.002	11	view →
LUAD	OS	Tertile	III,IV	0.861	0.349	.006	7	view →
PDAC	OS	Median	All	0.396	0.560	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NACC1–HNSC (OS)

Open the HNSC breakdown →