NACC1

Across TCGA patient cohorts, NACC1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NACC1-associated genes across cancer lineages are PRDX1, Shc_pY317, and eEF2. Each is linked with NACC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NACC1-to-partner and partner-to-NACC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by NACC1-low versus NACC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NACC1→partner) and Y-score (partner→NACC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRDX1 →	+0.162	+2.222	.045	.010	3	2
UCEC	Shc_pY317 →	-0.119	-2.321	.045	.034	3	2
UCEC	eEF2 →	+0.333	+2.321	.017	.033	3	1
UCEC	EGFR_pY1068 →	-0.272	-3.700	.005	.001	3	1
UCEC	eIF4E →	+0.223	+2.807	.007	.003	3	1
UCEC	GAPDH →	+0.422	+1.874	.045	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

PRDX1 by NACC1 expression — UCEC

Explore this box plot interactively →