NACC1

Across TCGA cell cohorts, NACC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,373 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NACC1-associated GO terms across cancer lineages are Positive regulation of mitotic cytokinesis, Regulation of anaphase-promoting complex-dependent catabolic process, and Chromosome condensation. Each is linked with NACC1 in more than 17 cancer types. Because this analysis shows association rather than direction, both NACC1-to-partner and partner-to-NACC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitotic cytokinesis grouped by NACC1-low versus NACC1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NACC1→partner) and Y-score (partner→NACC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Positive regulation of mitotic cytokinesis →	+0.141	+0.911	.003	.002	3	18
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.215	+1.249	.004	<.001	3	16
KIDNEY	Chromosome condensation →	+0.148	+0.946	<.001	.009	3	16
PANCREAS	RNA export from nucleus →	+0.100	+1.049	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Negative regulation of protein localization to chromatin →	+0.169	+1.027	.005	.008	2	16
BONE	CAMP/PKA signal transduction →	+0.222	+1.151	.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,373 associations by consensus.

Positive regulation of mitotic cytokinesis by NACC1 expression — BLOOD_Myeloma

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