NACC1

Across TCGA cell cohorts, NACC1 mutation is significantly associated with the RNA expression of many other genes, with 891 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NACC1-associated genes across cancer lineages are HPCAL4, LRRC3C, and GIMD1. Each is linked with NACC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NACC1-to-partner and partner-to-NACC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HPCAL4 grouped by NACC1-low versus NACC1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NACC1→partner) and Y-score (partner→NACC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HPCAL4 →	+0.363	+3.562	<.001	.007	3	2
LARGE_INTESTINE	LRRC3C →	+0.216	+2.362	.001	.006	3	2
BLOOD_Leukemia	GIMD1 →	+0.019	+2.982	<.001	.007	3	2
LARGE_INTESTINE	SH3GL2 →	+1.406	+3.474	<.001	.003	3	2
BLOOD_Lymphoma	OR5P2 →	+0.021	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	SI →	+0.023	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 891 associations by consensus.

HPCAL4 by NACC1 expression — BLOOD_Leukemia

Explore this box plot interactively →