NACAP5

Across TCGA pan-cancer cohorts, NACAP5 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated NACAP5 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher NACAP5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NACAP5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and ESCA show a favorable association.

CESC, SKCM, and UCEC are the cancer types where NACAP5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	IV	0.226	0.630	.012	36	view →
SKCM	DFS	Tertile	All	0.135	0.227	.005	35	view →
UCEC	OS	Tertile	III,IV	0.775	0.500	.010	28	view →
ESCA	OS	Median	III,IV	0.714	0.404	<.001	24	view →
BLCA	DFS	Tertile	All	0.522	0.647	.024	21	view →
TGCT	DFS	Tertile	All	0.558	0.830	.004	18	view →
LUSC	OS	Tertile	III,IV	0.386	0.800	.002	18	view →
CHOL	OS	Tertile	II,III,IV	1.000	0.417	.028	15	view →
LIHC	DFS	Tertile	II,III,IV	0.303	0.542	.017	15	view →
BRCA	DFS	Tertile	III,IV	0.957	0.859	.014	12	view →
COAD	DFS	Tertile	All	0.850	0.768	.038	12	view →
READ	DFS	Tertile	III,IV	1.000	0.638	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

NACAP5–CESC (OS)

Open the CESC breakdown →