NACA2

Across TCGA patient cohorts, NACA2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NACA2-associated genes across cancer lineages are EGFR_pY1068, ERK2, and Ku80. Each is linked with NACA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NACA2-to-partner and partner-to-NACA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NACA2-low versus NACA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NACA2→partner) and Y-score (partner→NACA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.303	-3.169	.027	.020	3	1
UCEC	ERK2 →	+0.259	+3.169	.014	.020	3	1
UCEC	Ku80 →	+0.317	+3.183	.014	.010	3	1
UCEC	Smad3 →	+0.219	+3.000	.008	.036	3	1
UCEC	YB-1_pS102 →	-0.253	-3.169	.012	.020	3	1
UCEC	Bak →	+0.345	+3.169	.012	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR_pY1068 by NACA2 expression — UCEC

Explore this box plot interactively →