NAB2

Across TCGA pan-cancer cohorts, NAB2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NAB2 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NAB2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NAB2 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

UCEC, HNSC, and CCRCC are the cancer types where NAB2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.638	1.000	.014	32	view →
HNSC	OS	Quartile	All	0.825	0.924	.010	26	view →
CCRCC	OS	Tertile	III,IV	0.444	0.794	.003	14	view →
PDAC	OS	Quartile	II,III,IV	0.310	0.702	.006	10	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.849	.021	8	view →
LUAD	OS	Tertile	III,IV	0.723	0.997	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NAB2–UCEC (OS)

Open the UCEC breakdown →