NAB2

Across TCGA patient cohorts, NAB2 mutation is significantly associated with the RNA expression of many other genes, with 2,570 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAB2-associated genes across cancer lineages are MIR4733, POLR3KP2, and SEPTIN7P4. Each is linked with NAB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAB2-to-partner and partner-to-NAB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4733 grouped by NAB2-low versus NAB2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAB2→partner) and Y-score (partner→NAB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4733 →	+0.385	+3.669	<.001	.006	3	2
SKCM	POLR3KP2 →	+0.127	+4.199	<.001	.009	3	2
BRCA	SEPTIN7P4 →	+0.253	+7.133	<.001	<.001	3	2
UCEC	CCL4 →	+0.908	+3.269	<.001	<.001	3	2
UCEC	CENPM →	+0.559	+3.700	.006	.001	3	2
UCEC	TOMM22 →	+0.387	+3.595	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,570 associations by consensus.

MIR4733 by NAB2 expression — SKCM

Explore this box plot interactively →