NAB2

Across TCGA cell cohorts, NAB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,021 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NAB2-associated GO terms across cancer lineages are Negative regulation of transcription by RNA polymerase III, Positive regulation of TORC2 signaling, and Regulation of smoothened signaling pathway. Each is linked with NAB2 in more than 12 cancer types. Because this analysis shows association rather than direction, both NAB2-to-partner and partner-to-NAB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of transcription by RNA polymerase III grouped by NAB2-low versus NAB2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NAB2→partner) and Y-score (partner→NAB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of transcription by RNA polymerase III →	+0.178	+1.281	<.001	<.001	3	13
SKIN	Positive regulation of TORC2 signaling →	+0.099	+0.875	<.001	<.001	3	11
LARGE_INTESTINE	Regulation of smoothened signaling pathway →	+0.048	+1.290	<.001	<.001	3	11
BREAST	Epigenetic regulation of gene expression →	+0.063	+1.044	<.001	.001	3	11
BLOOD_Lymphoma	Fructose 1,6-bisphosphate metabolic process →	+0.162	+1.604	<.001	<.001	3	11
BONE	Positive regulation of DNA metabolic process →	+0.075	+0.891	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,021 associations by consensus.

Negative regulation of transcription by RNA polymerase III by NAB2 expression — BONE

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