NAB2

Across TCGA cell cohorts, NAB2 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NAB2-associated genes across cancer lineages are KLF1, FGF8, and MAGEB4. Each is linked with NAB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAB2-to-partner and partner-to-NAB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLF1 grouped by NAB2-low versus NAB2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAB2→partner) and Y-score (partner→NAB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KLF1 →	+0.115	+3.215	<.001	.009	3	1
LARGE_INTESTINE	FGF8 →	+0.364	+3.160	<.001	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1
LARGE_INTESTINE	VHL →	+0.817	+3.067	<.001	.009	3	1
LARGE_INTESTINE	APLNR →	+0.205	+3.063	.002	.002	3	1
LARGE_INTESTINE	MSGN1 →	+0.061	+3.023	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

KLF1 by NAB2 expression — LARGE_INTESTINE

Explore this box plot interactively →