NAB1

Across TCGA patient cohorts, NAB1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAB1-associated genes across cancer lineages are MSH2, C-Raf, and 14-3-3_beta. Each is linked with NAB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAB1-to-partner and partner-to-NAB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by NAB1-low versus NAB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAB1→partner) and Y-score (partner→NAB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.313	-3.433	<.001	.005	3	2
UCEC	C-Raf →	+0.129	+1.807	.014	.025	3	2
UCEC	14-3-3_beta →	-0.111	-3.295	.002	.009	3	1
UCEC	eEF2 →	+0.275	+2.321	.036	.034	3	1
UCEC	EGFR_pY1068 →	-0.236	-2.321	.010	.005	3	1
UCEC	eIF4E →	+0.229	+2.906	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

MSH2 by NAB1 expression — UCEC

Explore this box plot interactively →